Introduction

Revlixen 10 mg Capsule contains Lenalidomide, an immunomodulatory drug primarily used in the treatment of various hematological cancers. It is known for its potent anti-cancer, antiangiogenic, and immunomodulatory effects. Revlixen is manufactured by Everest Pharmaceuticals Ltd and is supplied globally by Onco Solution — your trusted oncology medicine partner.

Key Benefits

• Highly effective in treating multiple myeloma (MM) and myelodysplastic syndromes (MDS)
• Extends maintenance therapy for MM patients post-stem cell transplant
• Suitable for relapsed/refractory mantle cell lymphoma (MCL)
• Effective in combination therapy for follicular lymphoma (FL) and marginal zone lymphoma (MZL)
• Manufactured under stringent GMP compliance

Indications

Revlixen 10 mg is indicated for:

• Multiple Myeloma (MM): In combination with Dexamethasone or as maintenance therapy after autologous hematopoietic stem cell transplantation (auto-HSCT).
• Myelodysplastic Syndromes (MDS): For transfusion-dependent anemia associated with 5q cytogenetic abnormalities.
• Mantle Cell Lymphoma (MCL): For patients with relapsed or progressed disease after two prior therapies.
• Follicular Lymphoma (FL) & Marginal Zone Lymphoma (MZL): In combination with Rituximab for previously treated cases.

Dosage & Administration

Maintenance Therapy Post auto-HSCT:

• Start with 10 mg once daily on Days 1-28 in 28-day cycles.
• If tolerated, increase to 15 mg after 3 cycles.

For MDS:

• 10 mg daily until disease progression or toxicity.

Administration Guidelines:

• Swallow the capsule whole with water.
• Take at the same time daily, with or without food.

Pharmacology

Lenalidomide works by targeting cereblon, a protein in the ubiquitin ligase complex. This leads to degradation of transcription factors (Ikaros, Aiolos), modulating the immune response and exerting anti-tumor effects. It inhibits cancer cell proliferation, induces apoptosis, and enhances NK and T-cell activity. It also reduces inflammatory cytokines like TNF-α and IL-6.

Pharmacokinetics:

• Absorption: Rapid; peak plasma levels in 0.5–6 hours
• Distribution: ~30% plasma protein binding
• Metabolism: Minimal metabolism; largely excreted unchanged
• Elimination: Primarily renal; ~82% via urine within 24 hours

Drug Interactions

• Digoxin: May increase Digoxin levels; monitor plasma levels.
• Warfarin: No significant interactions observed, but monitor PT/INR.
• Thrombosis Risk: Use with caution alongside erythropoietic or estrogenic agents.

Contraindications

• Pregnancy: Causes severe fetal harm; contraindicated in pregnant females.
• Severe Hypersensitivity: Includes reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis.

Side Effects

• Embryo-fetal toxicity
• Blood disorders: Neutropenia, thrombocytopenia
• Risk of thromboembolism (DVT, PE)
• Secondary malignancies
• Hepatotoxicity
• Severe skin reactions (SJS, TEN, DRESS)
• Tumor lysis syndrome
• Thyroid dysfunction

Special Populations

• Pediatrics: Not established for patients under 18 years
• Lactation: Unknown if excreted in breast milk. Avoid breastfeeding.

Precautions & Warnings

• REMS Program: Only available through Revlixen REMS for safety.
• Hematologic Monitoring: Frequent CBC tests required during treatment.
• Thromboprophylaxis: Recommended due to high VTE/ATE risks.
• Liver Monitoring: Monitor liver enzymes during therapy.
• Stem Cell Mobilization: Early referral for transplant planning is advised.

Overdose

There is no specific antidote for Lenalidomide overdose. Symptomatic management and supportive care are recommended.

Storage Conditions

• Store below 30°C
• Protect from moisture and light
• Keep out of reach of children

Manufacturer & Supplier Info

Manufacturer: Everest Pharmaceuticals Ltd
Global Supplier: Onco Solution – A Leading Worldwide Oncology Medicine Supplier

Conclusion

Revlixen 10 mg (Lenalidomide) Capsule is a proven, globally trusted oncology medication for treating hematologic malignancies. Onco Solution ensures consistent worldwide access to high-quality oncology treatments like Revlixen. Contact us for bulk supply or product queries.