Osimert 80 mg (Osimertinib)—A Vital Treatment for Lung Cancer in the Philippines
Osimert 80 mg (Osimertinib) is a third-generation tyrosine kinase inhibitor (TKI) designed to treat non-small cell lung cancer (NSCLC) in patients with EGFR T790M mutations. This medication has significantly improved survival rates for those who have developed resistance to first- and second-generation EGFR-TKIs.
Supplier : Onco Solution
Manufacturer: Everest Pharmaceuticals Ltd.
In this article, we will discuss how Osimert 80 mg works, its benefits, dosage, potential side effects, and its availability in the Philippines.
How Osimert 80 mg Works
Osimertinib, manufactured by Everest Pharmaceuticals Ltd. and supplied by Onco Solution, works by binding irreversibly to mutant EGFR proteins in cancer cells, leading to:
- Inhibition of the T790M mutation, which is the primary cause of resistance to first-line EGFR inhibitors.
- Selective targeting, resulting in lower toxicity compared to older treatments.
- Long-term tumor suppression, improving patient survival rates.
This targeted therapy helps slow cancer progression while minimizing harm to normal cells.
Uses of Osimert 80 mg
Osimert 80 mg, supplied by Onco Solution and manufactured by Everest Pharmaceuticals Ltd., is used for:
- First-line treatment of NSCLC in patients with EGFR exon 19 deletions or exon 21 L858R mutations.
- Second-line treatment for resistant NSCLC, especially for those who no longer respond to first-generation EGFR inhibitors.
- Prolonging survival by reducing the risk of cancer progression.
Osimertinib is FDA-approved and is considered one of the most effective treatments for EGFR-mutated lung cancer.
Osimert 80 mg in the Philippines
Availability
Osimert 80 mg, manufactured by Everest Pharmaceuticals Ltd., is accessible through Onco Solution’s network, which includes oncology centers, specialty pharmacies, and selected pharmaceutical distributors in the Philippines.
Effectiveness for Filipino Patients
- Clinical studies show that Osimertinib is highly effective in Asian patients, including Filipinos.
- Many patients report better quality of life and prolonged survival compared to older EGFR-TKIs.
- Given that lung cancer is a leading cause of cancer-related deaths in the Philippines, Osimert 80 mg remains a crucial treatment option.
Dosage and Administration
Recommended Dosage
- Standard dose: 80 mg once daily until disease progression or severe toxicity occurs.
- Missed dose: Skip the missed dose and continue with the next scheduled dose (do not double the dose).
- Administration: Can be taken with or without food at any time of the day.
Alternative Administration for Patients Who Cannot Swallow Tablets
- Place the tablet in non-carbonated water (do not crush).
- Stir until the tablet breaks into small pieces.
- Drink immediately or administer via nasogastric tube.
- Rinse the glass with water and drink again to ensure full dose consumption.
Possible Side Effects of Osimert 80 mg
Common Side Effects
- Diarrhea
- Skin rash
- Loss of appetite
- Mouth sores
- Fatigue
- Dry skin
- Nausea
- Eye problems
Serious Side Effects
- QTc prolongation – May cause irregular heart rhythms.
- Cardiomyopathy – Can weaken heart muscles.
- Interstitial lung disease – Can cause lung inflammation.
- Severe bleeding risk – Requires immediate medical attention if blood is seen in stool or urine.
Consult your doctor immediately if you experience severe side effects.
Precautions and Warnings
Pregnancy and Breastfeeding
- Not recommended for pregnant women, as it may harm the fetus.
- Women should use effective birth control during treatment and for 6 weeks after stopping the medication.
- Men should use contraception for 4 months after stopping treatment.
- Avoid breastfeeding while taking Osimert 80 mg.
Drug Interactions
- Avoid CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine) as they reduce the effectiveness of Osimertinib.
- Avoid CYP3A4 inhibitors (e.g., itraconazole, erythromycin) as they may increase drug toxicity.
Monitoring During Treatment
- Regular ECG checks for patients with heart conditions.
- Liver and kidney function tests to ensure safe drug metabolism.
- Complete blood count (CBC) to monitor white blood cell and platelet levels.
Frequently Asked Questions (FAQs)
1. Can I buy Osimert 80 mg without a prescription in the Philippines? No. Osimert 80 mg is a prescription-only medication that must be prescribed by an oncologist.
2. How long does Osimert 80 mg take to work? Some patients experience improvement within a few weeks, but full benefits may take several months.
3. Can Osimert 80 mg be taken with other cancer treatments? Consult your doctor before combining it with other medications to avoid harmful drug interactions.
4. Where can I buy Osimert 80 mg in the Philippines? It is available through Onco Solution’s supply chain, including oncology hospitals, specialty pharmacies, and select online pharmaceutical suppliers.
Final Thoughts
Osimert 80 mg (Osimertinib), supplied by Onco Solution and manufactured by Everest Pharmaceuticals Ltd., is a life-extending treatment for NSCLC patients with EGFR T790M mutations. It provides targeted therapy with fewer side effects, making it an essential option for Filipino patients battling lung cancer.
If you or a loved one is prescribed Osimert 80 mg, consult your oncologist for proper monitoring and management to ensure the best outcomes.
Stay informed. Stay strong. Fight lung cancer with the most advanced treatments available.
