Introduction

Oxator 100 mg (Oxaliplatin) Injection is a platinum-based chemotherapy medication widely used for the treatment of colorectal cancer. Manufactured by Eskayef Pharmaceuticals Limited, this potent oncology drug is supplied globally by Onco Solution. Oxator 100 mg (Oxaliplatin) Injection is primarily used in combination with 5-fluorouracil (5-FU) and leucovorin to treat patients diagnosed with stage III colon cancer after complete surgical resection and for those with advanced colorectal cancer.

Indications

Oxator 100 mg (Oxaliplatin) Injection is indicated for:

• Adjuvant treatment of stage III colon cancer following the surgical removal of the primary tumor.
• Treatment of advanced colorectal cancer, often combined with infusional 5-FU and leucovorin.

Pharmacology

Oxaliplatin, the active ingredient in Oxator 100 mg, belongs to the platinum-based antineoplastic agents. It works by forming cross-links with DNA after undergoing intracellular hydrolysis. These cross-links inhibit DNA replication and transcription, eventually leading to cancer cell apoptosis (cell death). Oxaliplatin is known for its superior efficacy over traditional platinum compounds like cisplatin.

Dosage & Administration

Intravenous (IV) Administration for Adults:

1. Stage III Colon Cancer (Adjuvant Therapy):
   • Dose: 85 mg/m² IV infusion over 2-6 hours.
   • Frequency: Every 2 weeks for 12 cycles.
   • Dilution: Dissolve in 250-500 ml of 5% glucose solution.
   • Adjustment: If toxicity occurs, reduce the dose to 75 mg/m².
2. Advanced Colorectal Cancer:
   • Dose: 85 mg/m² IV infusion over 2-6 hours.
   • Frequency: Every 2 weeks until disease progression or unacceptable toxicity occurs.
   • Adjustment: If toxicity occurs, reduce the dose to 65 mg/m².

Note: Oxator 100 mg (Oxaliplatin) Injection should be administered before fluoropyrimidines to enhance effectiveness.

Drug Interactions

• Digoxin: Oxator may decrease plasma levels of digoxin.
• Nephrotoxic Drugs: Concomitant use increases toxicity risk.
• Taxane Derivatives: If used sequentially, docetaxel or paclitaxel should be administered before Oxator to prevent myelosuppression.

Contraindications

• Pregnancy (Category D: Risk to fetus but benefits may outweigh risks in life-threatening cases).
• Severe peripheral neuropathy causing functional impairment.
• Severe renal impairment.

Side Effects

Patients receiving Oxator 100 mg (Oxaliplatin) Injection may experience:

• Neurological Symptoms: Peripheral neuropathy, pharyngolaryngeal dysesthesia.
• Gastrointestinal Issues: Nausea, vomiting, diarrhea, stomatitis, constipation.
• Hematological Effects: Anemia, leukopenia, thrombocytopenia.
• Other Effects: Fatigue, fever, dyspnea, back pain, allergic reactions, hand-foot syndrome.

Pregnancy & Lactation

• Pregnancy Category D: Use only if necessary in life-threatening conditions.
• Lactation: Caution advised due to the potential risk to the infant.

Precautions & Warnings

• Administered only by experienced oncology specialists.
• Monitor blood counts regularly and adjust the dose as required.
• Use with caution in elderly patients and those with moderate renal impairment.
• Avoid aluminum-containing IV sets as they degrade platinum compounds.
• Proper handling and disposal required due to cytotoxic properties.

Use in Special Populations

• Renal Impairment: Dose adjustment may be required.
• Elderly Patients: Close monitoring for toxicity is necessary.

Overdose Effects

Symptoms include thrombocytopenia, myelosuppression, neurotoxicity, nausea, and vomiting. Management involves supportive care.

Reconstitution & Storage

• Reconstitution: Dissolve with 10 ml (for 50 mg vial) or 20 ml (for 100 mg vial) of water for injection or 5% dextrose.
• Dilution: Further dilute with 250-500 ml of 5% dextrose before administration.
• Storage Conditions:
  • Intact vials: 15-30°C, do not freeze.
  • Reconstituted solution: 2-8°C for up to 24 hours.
  • Diluted solution: Stable for 6 hours at room temperature or 24 hours under refrigeration (2-8°C).

Supplier Information

Onco Solution is a global oncology medicine supplier committed to providing high-quality cancer treatment solutions. Oxator 100 mg (Oxaliplatin) Injection is one of its many life-saving chemotherapy products. For more information, visit www.oncosolution.com****.

Manufacturer Information

Oxator 100 mg (Oxaliplatin) Injection is manufactured by Eskayef Pharmaceuticals Limited, a leading pharmaceutical company in Bangladesh. Established in 1990, Eskayef has built a reputation for manufacturing high-quality oncology and specialty medicines. For details, visit www.skfbd.com****.

Conclusion

Oxator 100 mg (Oxaliplatin) Injection is an effective chemotherapy drug for colon and colorectal cancer. Administered under strict medical supervision, it plays a crucial role in improving survival rates in cancer patients. Onco Solution, as the global distributor, ensures its availability across the world, while Eskayef Pharmaceuticals Limited upholds stringent manufacturing standards. For medical inquiries, always consult an oncology specialist before administration.